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L-Serine-13C3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-Serine-13C3图片
CAS NO:201595-68-8
包装与价格:
包装价格(元)
500 µg电议
1mg电议
5mg电议

产品介绍
L-Serine-13C3 ((-)-Serine-13C3) 是 13C 标记的 L-丝氨酸。 L-丝氨酸((-)-丝氨酸;(S)-丝氨酸),一种所谓的非必需氨基酸,在细胞增殖中起核心作用。
Cas No.201595-68-8
别名L-丝氨酸-13C3,(-)-Serine-13C3; (S)-Serine-13C3
Canonical SMILESO[13C]([13C@@H](N)[13CH2]O)=O
分子式[13C]3H7O3
分子量108.1
溶解度Water: slightly, sonicated
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

L-Serine-13C3is intended for use as an internal standard for the quantification of L-serine by GC- or LC-MS. L-Serine is a non-essential amino acid.1It is produced from 3-phosphoglycerate in a multistep biosynthesis catalyzed by phosphoglycerate dehydrogenase (PGDH), phosphoserine aminotransferase (PSAT), and phosphoserine phosphatase (PSP). L-Serine can also be derived from dietary sources, as well as protein and phospholipid turnover. Defective L-serine biosynthesis is associated with neural tube defects and deoxysphingolipid accumulation in patients with Neu-Laxova syndrome, a rare disease characterized by a mutation inPGDH.1,2Dysregulation of L-serine phosphorylation is associated with disease progression in patients with neurodegenerative diseases, including Alzheimer’s disease and amyotrophic lateral sclerosis.

1.Holm, L.J., and Buschard, K.L-serine: A neglected amino acid with a potential therapeutic role in diabetesAPMIS127(10)655-659(2019) 2.Metcalf, J.S., Dunlop, R.A., Powell, J.T., et al.L-serine: A naturally-occurring amino acid with therapeutic potentialNeurotox. Res.33(1)213-221(2018)