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Chlorpheniramine-d6(maleate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Chlorpheniramine-d6(maleate)图片
CAS NO:1219806-45-7
包装与价格:
包装价格(元)
500 µg电议
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of chlorpheniramine
Cas No.1219806-45-7
别名马来酸氯苯那敏-D6,(R)-(-)-Chlorpheniramine maleate-d6; L-Chlorpheniramine maleate-d6
Canonical SMILESClC(C=C1)=CC=C1C(CCN(C([2H])([2H])[2H])C([2H])([2H])[2H])C2=CC=CC=N2.OC(/C=C\C(O)=O)=O
分子式C16H13ClD6N2• C4H4O4
分子量396.9
溶解度Methanol: slightly,Water: slightly
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Chlorpheniramine-d6is intended for use as an internal standard for the quantification of chlorpheniramine by GC- or LC-MS. Chlorpheniramine is a histamine H1receptor antagonist with an IC75value of 0.0016 μg/ml for reversal of histamine-induced spasms in isolated guinea pig ileum.1It protects against intravenous histamine-induced death (PD50= 0.15 mg/kg) and delays induction of aerosolized histamine-induced coughing (ED100sec= 0.44 mg/kg) in guinea pigs. Chlorpheniramine (20 mg/kg, i.p.) prevents histamine-induced passive cutaneous anaphylaxis (PCA) in rabbits.2It also reduces respiratory resistance and hypersecretion of tracheobronchial fluid in a dog model of histamine-induced asthma.3Formulations containing chlorpheniramine have been used in the treatment of seasonal allergies.

1.Lish, P.M., Robbins, S.I., and Peters, E.L.Specificity of antihistamine drugs and involvement of the adrenergic system in histamine deaths in the guinea pigJ. Pharmacol. Exp. Ther.153(3)538-543(1966) 2.Henson, P.M., and Cochrane, C.G.Immunological induction of increased vascular permeability. I. A rabbit passive cutaneous anaphylactic reaction requiring complement, platelets, and neutrophilsJ. Exp. Med.129(1)153-165(1969) 3.Yamatake, Y., Sasagawa, S., Yanaura, S., et al.Involvement of histamine H1- and H2-receptors in induced asthmas in dogsJpn. J. Pharmacol.27(6)791-797(1977)