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p,p'-DDE
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
p,p'-DDE图片
CAS NO:72-55-9
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
p,p'-DDE (4,4'-DDE) 是持久性二氯二苯三氯乙烷 (DDT) 的主要代谢物,是一种有效的雄激素受体拮抗剂,IC50 为 5 μM,Ki 为 3.5 μM。
Cas No.72-55-9
别名2,2-双(4-氯苯基)-1,1-二氯乙烯,4,4'-DDE; p,p'-Dichlorodiphenyldichloroethylene
Canonical SMILESClC1=CC=C(/C(C2=CC=C(Cl)C=C2)=C(Cl)\Cl)C=C1
分子式C14H8Cl4
分子量318
溶解度Chloroform: Slightly Soluble
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

p,p'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT. It accumulates in smallmouth buffalo, channel catfish, and largemouth bass as well as sediment in the Huntsville Spring Branch-Indian Creek tributary system surrounding a DDT manufacturing plant where it is considered a persistent organic pollutant (POP). p,p'-DDE inhibits estrogen binding to rainbow trout estrogen receptors (rtERs) with an IC50 value of 8 µM. It induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles. p,p'-DDE (50-100 µM) also decreases ATP levels, the proportion of sperm with high mitochondrial membrane potential, and motility of human sperm in vitro.