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Ganglioside GT1b Mixture(sodium salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ganglioside GT1b Mixture(sodium salt)图片
CAS NO:59247-13-1
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
Cas No.59247-13-1
别名三唾液酸神经节甘酯GT1B,Ganglioside G1 Mixture
Canonical SMILESCCCCCCCCCCCCC/C=C/[C@]([H])([C@](NC(CCCCCCCCCCCCCCCCC)=O)([H])CO[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O[C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2O)O[C@@]3(C([O-])=O)O[C@H]([C@@H]([C@H](C3)O)NC(C)=O)[C@@H](O)[C@H](O[C@@]4(C([O-])=O)O[C@H]([C@@H]([C@H](C4)O)N
分子式C95H162N5O47•3Na
分子量2126.3
溶解度Chloroform:Methanol (2:1): Soluble, Water: micellar aggregates
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. It binds to the neurotoxins botulinum toxin serotype A (BTxA), BTxA heavy chain, and tetanus toxin with IC50 values of 11, 0.74, and 7.2 μM, respectively.[1] Ganglioside GT1b-containing liposomes bind to the major coat protein VP1 from Merkel cell polyomavirus (MCPyV), which has been identified in Merkel cell carcinomas, identifying ganglioside GT1b as a putative MCPyV receptor. [2] Ganglioside GT1b decreases production of IL-6, IL-10, IgG, IgM, and IgA in human peripheral blood mononuclear cells (PBMCs) by 31.4, 30.5, 60, 59.5, and 58%, respectively, when used at a concentration of 10 μM [3] . Ganglioside GT1b mixture contains ganglioside GT1b molecular species with C18:1 and C20:1 sphingoid backbones.

Reference:
[1]. Schengrund, C.-L., DasGupta, B.R., and Ringler, N.J. Binding of botulinum and tetanus neurotoxins to ganglioside GT1b and derivatives thereof. J. Neurochem. 57(3), 1024-1032 (1991).
[2]. Erickson, K.D., Garcea, R.L., and Tsai, B. Ganglioside GT1b is a putative host cell receptor for the Merkel cell polyomavirus. J. Virol. 83(19), 10275-10279 (2009).
[3]. Kanda, N., and Tamaki, K. Ganglioside GT1b suppresses immunoglobulin production by human peripheral blood mononuclear cells. Immunology 96(4), 628-633 (1999).