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KM 233
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KM 233图片
CAS NO:628263-22-9
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
KM 233 是一种经典的大麻素,具有良好的血脑屏障渗透性。相对于 THC,KM 233 对 CB2 受体具有选择性亲和力。 KM 233 可有效降低 U87 胶质瘤肿瘤负担,可用于胶质瘤研究。
Cas No.628263-22-9
Canonical SMILESCC(C1=CC=CC=C1)(C)C2=CC(O)=C3C(OC(C)(C)[C@H]4[C@H]3CC(C)=CC4)=C2
分子式C25H30O2
分子量362.5
溶解度DMF: 30 mg/ml,DMF:PBS(pH7.2) (1:2): 0.3 mg/ml,DMSO: 20 mg/ml,Ethanol: 3 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Because selective activation of peripheral cannabinoid (CB2) receptors in rat C-6 glioma cells has been shown to induce apoptosis through enhanced ceramide synthesis de novo, CB2 agonists present potential as anti glioma agents. KM 233 is a δ8-tetrahydrocannabinol analog with a dimethyl substitution that exhibits high binding affinity for both the CB1 and CB2 receptors with 13-fold selectivity for the CB2 receptor (Kis = 12.3 and 0.91 nM, respectively). Demonstrating good lipophilicity and ability to penetrate the blood brain barrier, KM 233 inhibits human U87 glioma cell proliferation in vitro with an IC50 value of 1.4 μM and significantly reduces U87 glioma tumor size in vivo at a dose of 2 mg/kg in a SCID mouse xenograft side-pocket model.