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NO-Indomethacin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NO-Indomethacin图片
CAS NO:301838-28-8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
Cas No.301838-28-8
Canonical SMILESO=C(C1=CC=C(Cl)C=C1)N2C3=C(C=C(OC)C=C3)C(CC(SC[C@H](N(C(C)=O)[H])C(OCCCCO[N+]([O-])=O)=O)=O)=C2C
分子式C28H30ClN3O9S
分子量620.1
溶解度DMF: 30 mg/ml,DMF:PBS (pH 7.2)(1:1): .5 mg/ml,DMSO: 20 mg/ml,Ethanol: .5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NO-indomethacin is a hybrid molecule of indomethacin and a nitric oxide (NO) donor. This drug design combines the anti-inflammatory properties of a non-steroidal anti-inflammatory drug (NSAID) with the gastrointestinal protective effects of NO. Compounds of this class retain their anti-inflammatory and analgesic activity, but have reduced gastrointestinal and kidney toxicity compared to the NSAID alone. NO-indomethacin also enhances the cancer chemopreventative activity of indomethacin. NO-indomethacin exhibits an IC50 of 82 µM, compared to >1,000 µM for indomethacin alone, for the inhibition of pancreatic cancer cell (PaCa-2) growth after 24 hours in culture.