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Decanoic Acid-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Decanoic Acid-d3图片
CAS NO:102611-15-4
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
An internal standard for the quantification of decanoic acid
Cas No.102611-15-4
别名癸酸 d3
Canonical SMILESOC(CCCCCCCCC([2H])([2H])[2H])=O
分子式C10H17D3O2
分子量175.3
溶解度DMF: 25 mg/ml,DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml,DMSO: 10 mg/ml,Ethanol: 25 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Decanoic acid-d3 is intended for use as an internal standard for the quantification of decanoic acid by GC- or LC-MS. Decanoic acid is a medium-chain saturated fatty acid. It is a non-competitive antagonist at AMPA receptors that selectively reduces glutamate-induced currents in Xenopus oocytes expressing GluA2 and GluA3 subunit-containing AMPA receptors (IC50 = 0.52 mM) over those expressing GluA1 (IC50 = 2.09 mM) or GluA1 and GluA2 subunits (IC50 = 1.16 mM).1 It inhibits epileptiform activity induced by pentylenetetrazole or low magnesium in rat hippocampal slices. Decanoic acid (1 mM) induces contractions in isolated guinea pig duodenum, an effect that can be blocked by the muscarinic acetylcholine receptor antagonist hyoscine, voltage-gated sodium channel inhibitor tetrodotoxin , or M2 muscarinic acetylcholine receptor antagonist hexamethonium .2 It increases the escape threshold in an orofacial mechanical stimulation test in rats when administered at a topical dose of 30% in ointment form, indicating analgesic activity.3 This effect can be blocked by the muscarinic acetylcholine receptor antagonist methoctramine . Plasma levels of decanoic acid are increased in patients with colorectal cancer when compared to patients with breast cancer or ulcerative colitis or without cancer.4

|1. Chang, P., Augustin, K., Boddum, K., et al. Seizure control by decanoic acid through direct AMPA receptor inhibition. Brain 139(Pt 2), 431-443 (2016).|2. Gwynne, R.M., Thomas, E.A., Goh, S.M., et al. Segmentation induced by intraluminal fatty acid in isolated guinea-pig duodenum and jejunum. J. Physiol. 556(Pt 2), 557-569 (2004).|3. Noguchi, Y., Matsuzawa, N., Akama, Y., et al. Dietary constituent, decanoic acid suppresses the excitability of nociceptive trigeminal neuronal activity associated with hypoalgesia via muscarinic M2 receptor signaling. Mol. Pain 13, 1-11 (2017).|4. Crotti, S., Agnoletto, E., Cancemi, G., et al. Altered plasma levels of decanoic acid in colorectal cancer as a new diagnostic biomarker. Anal. Bioanal. Chem. 408(23), 6321-6328 (2016).