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Nexinhib20
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Nexinhib20图片
CAS NO:331949-35-0
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
An inhibitor of Rab27a-JFC1 protein-protein interactions
Cas No.331949-35-0
化学名4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one
Canonical SMILESO=C(C(C)(C)C)/C(N1N=CN=C1)=C/C2=CC([N+]([O-])=O)=CC=C2
分子式C15H16N4O3
分子量300.3
溶解度15mg/mL in ethanol, 30mg/mL inn DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Nexinhib20 is an inhibitor of the protein-protein interaction between the small GTPase Rab27a and its effector JFC1 (IC50 = 2.6 μM).[1] It inhibits myeloperoxidase (MPO) secretion induced by granulocyte macrophage colony-stimulating factor (GM-CSF) and fMLP in isolated human neutrophils (IC50 = 0.33 μM). Nexinhib20 (30 mg/kg) reduces LPS-induced increases in plasma MPO levels, as well as LPS-induced hepatic and renal neutrophil infiltration in a mouse model of endotoxin-induced systemic inflammation.

Reference:
[1]. Johnson, J.L., Ramadass, M., He, J., et al. Identification of neutrophil exocytosis inhibitors (nexinhibs), small molecule inhibitors of neutrophil exocytosis and inflammation: Druggability of the small GTPase Rab27a. J. Biol. Chem. 291(50), 25965-25982 (2016).