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A 1070722
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
A 1070722图片
CAS NO:1384424-80-9
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
A 1070722 是一种有效的选择性糖原合酶激酶 3 (GSK-3) 抑制剂,对 GSK-3α 和 GSK-3β 的 Ki 均为 0.6 nM。 A 1070722 可以穿透血脑屏障 (BBB) 并在脑区积聚,因此有可能成为 PET 放射性示踪剂在脑中定量 GSK-3。
Cas No.1384424-80-9
化学名(Z)-N'-(7-methoxyquinolin-4-yl)-N-(6-(trifluoromethyl)pyridin-2-yl)carbamimidic acid
Canonical SMILESCOC1=CC2=NC=CC(/N=C(O)/NC3=CC=CC(C(F)(F)F)=N3)=C2C=C1
分子式C17H13F3N4O2
分子量362.31
溶解度<36.23mg/ml in DMSO
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

A 1070722 is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain[1].

References:
[1]. Prabhakaran J, et al. Radiosynthesis and in Vivo Evaluation of [11C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain. ACS Chem Neurosci. 2017 Aug 16;8(8):1697-1703.