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Tadalafil-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tadalafil-d3图片
CAS NO:960226-55-5
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of tadalafil
Cas No.960226-55-5
别名他达拉非-D3,IC-351-d3
Canonical SMILESO=C1N(C([2H])([2H])[2H])CC(N2[C@H](C3=CC=C(OCO4)C4=C3)C5=C(C6=CC=CC=C6N5)C[C@@]21[H])=O
分子式C22H16D3N3O4
分子量392.4
溶解度DMSO: Soluble,Methanol: Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tadalafil-d3is intended for use as an internal standard for the quantification of tadalafil by GC- or LC-MS. Tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC50= 1.2 nM).1It is selective for PDE5 over PDE1-4 and 7-10 (IC50s = 9.2-280 μM), however, it does also inhibit PDE11 (IC50= 11 nM).In vivo, tadalafil (10 mg/kg) decreases production of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 and improves renal function in a rat model of ischemia/reperfusion injury.2It also reduces development of tobacco smoke-induced emphysema and pulmonary hypertension in mice.3Formulations containing tadalafil have been used to treat erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction.

1.Card, G.L., England, B.P., Suzuki, Y., et al.Structural basis for the activity of drugs that inhibit phosphodiesterasesStructure12(12)2233-2247(2004) 2.Medeiros, V.F., Azevedo, Í.M., Carvalho, M.D., et al.The renoprotective effect of oral tadalafil pretreatment on ischemia/reperfusion injury in ratsActa. Cir. Bras.32(2)90-97(2017) 3.Seimetz, M., Parajuli, N., Pichl, A., et al.Cigarette smoke-induced emphysema and pulmonary hypertension can be prevented by phosphodiesterase 4 and 5 inhibition in micePLoS One10(6)e0129327(2015)