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Oxatomide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Oxatomide图片
CAS NO:60607-34-3
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Oxatomide是一种有效的具有口服活性的双重H1组胺受体(H1-histaminereceptor)和P2X7受体拮抗剂,具有抗组胺和抗过敏活性。Oxatomide几乎完全阻断人P2X7受体中ATP诱导的电流(IC50为0.95μM)。Oxatomide可抑制ATP诱导的Ca2+内流,IC50值为0.43μM,并且还抑制5-羟色胺(serotonin)。
Cas No.60607-34-3
别名欧诗美锭
Canonical SMILESO=C1NC2=CC=CC=C2N1CCCN3CCN(C(C4=CC=CC=C4)C5=CC=CC=C5)CC3
分子式C27H30N4O
分子量426.55
溶解度DMSO: 250 mg/mL (586.10 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Oxatomide is a potent and orally active dual H1-histamine receptor and P2X7 receptor antagonist with antihistamine and anti-allergic activity. Oxatomide almost completely blocks the ATP-induced current in human P2X7 receptors (IC50 of 0.95 μM). Oxatomide inhibits ATP-induced Ca2+ influx with an IC50 value of 0.43 μM and also inhibits serotonin[1][2].

[1]. Kazuki Yoshida, et al. P2X7 receptor antagonist activity of the anti-allergic agent oxatomide. Eur J Pharmacol. 2015 Nov 15;767:41-51. [2]. K Ohmori, et al. Pharmacological studies on oxatomide (KW-4354). (7) Antagonistic effects on chemical mediators. Nihon Yakurigaku Zasshi. 1983 May;81(5):399-409.