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MNS
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MNS图片
CAS NO:1485-00-3
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议

产品介绍
MNS (NSC 170724) 是一种 β-硝基苯乙烯衍生物,是一种有效的酪氨酸激酶抑制剂和广谱抗血小板剂。 MNS 完全抑制 U46619、ADP、花生四烯酸、胶原蛋白和凝血酶诱导的血小板聚集,IC50 值分别为 2.1、4.1、5.8、7.0 和 12.7 μM。 MNS 抑制 Src、Syk 和 FAK,IC50 分别为 27.3、2.8 和 97.6 μM。
Cas No.1485-00-3
别名3,4-亚甲二氧-beta-硝基苯乙烯,NSC 170724; 5-(2-Nitrovinyl)benzodioxole
化学名5-[(E)-2-nitroethenyl]-1,3-benzodioxole
Canonical SMILESC1OC2=C(O1)C=C(C=C2)C=C[N+](=O)[O-]
分子式C9H7NO4
分子量193.16
溶解度≥ 8mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MNS is a potent and selective inhibitor of Src and Syk tyrosine kinases. target: src, syk. [1]IC50:29.3 (src), 2.5 uM (syk); [1]In vitro: no direct effects on protein kinase C, Ca2+ mobilization, Ca2+-dependent enzymes, PKC activation. MNS potently prevents GPIIb/IIIa activation and platelet aggregation without directly affecting other signaling pathways required for platelet activation. [1] [2] MNS is much more potent than genistein in inhibiting platelet aggregation and protein tyrosine phosphorylation. [2]

References:
[1]. Wang WY et al. Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-beta-nitrostyrene, a novel tyrosinekinase inhibitor. Mol Pharmacol. 2006 Oct;70(4):1380-9.
[2]. Wang WY et al. Synthesis and pharmacological evaluation of novel beta-nitrostyrene derivatives as tyrosine kinase inhibitorswith potent antiplatelet activity. Biochem Pharmacol. 2007 Aug 15;74(4):601-11.