CAS NO: | 1202759-32-7 |
包装 | 价格(元) |
10mg | 电议 |
50mg | 电议 |
Cas No. | 1202759-32-7 |
化学名 | 4-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]-N-methylpyridine-2-carboxamide |
Canonical SMILES | CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)F |
分子式 | C26H22FN7O3 |
分子量 | 499.5 |
溶解度 | DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:6): 0.14 mg/ml,DMSO: 25 mg/ml |
储存条件 | Store at -20° C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | CNX-774 is an orally active and selective inhibitor of BTK with IC50 value of<1 nM. Bruton’s tyrosine kinase (BTK) is an important enzyme in the B-cell antigen receptor (BCR) signaling pathway and also plays an important role in mast cell activation and B cell maturation. CNX-774 is an orally active, irreversible and selective BTK inhibitor with IC50 value of<1 nM. CNX-774 formed covalent bond with the Cys481 residue within the ATP binding site of BTK. In cellular assays, CNX-774 inhibited BTK with IC50 values of 1-10 nM [1]. Reference: |