您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > R8-T198wt
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
R8-T198wt
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
R8-T198wt图片
CAS NO:2305815-72-7
包装:1mg
市场价:1460元

产品介绍
R8-T198wt 是一种细胞可渗透的羧基末端 p27Kip1 肽,通过抑制 Pim-1 激酶表现出抗肿瘤活性。
Cas No.2305815-72-7
化学名(1Z,4Z,6S,7Z,9S,10Z,12S,13Z,15S,16Z,18S,19Z,21S)-1-((S)-1-((2S,3Z,5S,6Z,8R,9Z,12Z,14S,15Z,17S,18Z,20S,21Z,23S,24Z,26S,27Z,29S,30Z,32S,33Z,35S,36Z,39Z,42Z)-44-amino-2,5-bis(4-aminobutyl)-14,17,20,23,26,29,32,35-octakis(3-guanidinopropyl)-4,7,10,13,16,19,22
Canonical SMILESCC(C[C@@](/N=C(O)/C/N=C(O)/[C@]1([H])CCCN1C([C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/C/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/C/N=C(O)/C/N=C(O)/CN)([H])CCCNC(N)=N)([H])CCCNC(N)=N)([H])C
分子式C111H211N59O26S
分子量2820.31
溶解度Soluble to 2 mg/ml in 20% acetonitrile / Water
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述 Cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. Inhibits Pim-1 phosphorylation of p27Kip1and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. Also inhibits Pim-1-dependent growth of DU145 cellsin vitroandin vivo. Displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM.