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Lavendustin A
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Lavendustin A图片
CAS NO:125697-92-9
包装:1mg
市场价:1080元

产品介绍
Lavendustin A (RG-14355) 是从 Streptomyces Griseolavendus 中分离出来的，是一种有效的、特异性的和 ATP 竞争性的酪氨酸激酶抑制剂，对 EGFR 相关酪氨酸激酶的 IC50 为 11 ng/mL。它抑制 VEGF 诱导的血管生成并阻断 LTPGABA-A 的诱导。
Cas No.125697-92-9
别名薰草菌素; RG-14355
化学名5-((2,5-dihydroxybenzyl)(2-hydroxybenzyl)amino)-2-hydroxybenzoic acid
Canonical SMILESOC(C(CN(C(C=C1C(O)=O)=CC=C1O)CC2=CC=CC=C2O)=C3)=CC=C3O
分子式C21H19NO6
分子量381.38
溶解度DMF: 20 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 15 mg/ml,Ethanol: 10 mg/ml
储存条件Desiccate at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Lavendustin A (RG-14355), isolated from Streptomyces Griseolavendus, is a potent, specific and ATP-competitive inhibitor of tyrosine kinase, with an IC50 of 11 ng/mL for EGFR-associated tyrosine kinase[1]. It suppresses VEGF-induced angiogenesis and blocks the induction of LTPGABA-A[2][3].

References:
[1]. Onoda T, et al. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J Nat Prod. 1989 Nov-Dec;52(6):1252-7.
[2]. Hu DE, et al. Suppression of VEGF-induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A. Br J Pharmacol. 1995 Jan;114(2):262-8.
[3]. Gubellini P, et al. Endogenous neurotrophins are required for the induction of GABAergic long-term potentiation in the neonatal rat hippocampus. J Neurosci. 2005 Jun 15;25(24):5796-802.