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Corylifol A
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Corylifol A图片
CAS NO:775351-88-7
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
Corylifol A 抑制 IL-6 诱导的 STAT3 活化和磷酸化，IC50 为 0.81 μM。
Cas No.775351-88-7
别名3-[3-[(2E)-3,7-二甲基-2,6-辛二烯-1-基]-4-羟基苯基]-7-羟基-4H-1-苯并吡喃-4-酮,Corylifol-A; Corylinin
Canonical SMILESOC1=CC=C(C2=COC3=CC(O)=CC=C3C2=O)C=C1C/C=C(CC/C=C(C)/C)\C
分子式C25H26O4
分子量390.47
溶解度Soluble in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Corylifol A inhibits IL-6-induced STAT3 activation and phosphorylation, with an IC50 of 0.81 μM.

Corylifol A shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 value of 0.81±0.15 μM, also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells[1]. Corylifol A inhibits SARA PLpro in a dose-dependent manner with IC50s ranging between 4.2 and 38.4 μM[2]. Corylifol A is found to be a naturally occurring potent inhibitor of hCE2, with low Ki values ranging from 0.62 μM to 3.89 μM[3].

References:
[1]. Lee SW, et al. Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation. Planta Med. 2012 Jun;78(9):903-6.
[2]. Kim DW, et al. Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia. J Enzyme Inhib Med Chem. 2014 Feb;29(1):59-63.
[3]. Li YG, et al. Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2. Fitoterapia. 2015 Jan 13;101C:99-106. d