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AGN 194078
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AGN 194078图片
CAS NO:321995-62-4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
AGN194078是一个有选择性的RARα激动剂,其Kd和EC50值分别为3和112nM。
Cas No.321995-62-4
Canonical SMILESO=C(O)C1=C(F)C=C(NC(C2=C(O)C=C3C(C)(C)CCC(C)(C)C3=C2)=O)C=C1F
分子式C22H23F2NO4
分子量403.42
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively.

AGN 194078 is a selective RARα agonist and binds to RARα with very high affinity, having a Kd value of 3 nM, while being unable to bind to RARβ and binding only very weakly (Kd=5600 nM) to RARγ. Furthermore, AGN 194078 maintains full transcriptional activity through RARα, with an EC50 value of 112 nM, but only activatedRARβ and RARγ with about 10% efficacy at the highest dose (1000 nM) tested[1].

[1]. Beard RL, et al. Synthesis and biological activity of retinoic acid receptor-alpha specific amides. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3145-8.