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ULK-101
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ULK-101图片
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
2mg电议
5mg电议
10mg电议

产品介绍
ULK-101是一个有效的、选择性的ULK1抑制剂,其在体外测得的对ULK1和ULK2的IC50值分别为1.6nM和30nM。ULK-101抑制自噬,使癌细胞对营养胁迫敏感。
Canonical SMILESFC1=CC=C(C(C=N2)=CN3C2=C(C4=CSC(C(N[C@@H](C5CC5)C(F)(F)F)=O)=C4)C=N3)C=C1
分子式C22H16F4N4OS
分子量460.45
溶解度DMSO : 83.33 mg/mL (180.98 mM);Water :< 0.1 mg/mL (insoluble)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ULK-101 is a potent and selective ULK1 inhibitor, with IC50 values of 1.6 nM and 30 nM for ULK1 and ULK2 in vitro, respectively. ULK-101 suppresses autophagy and sensitizes cancer cells to nutrient stress[1].

[1]. Martin KR, et al. A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress. iScience. 2018 Oct 26;8:74-84.