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UBCS039
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
UBCS039图片
CAS NO:358721-70-7
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
UBCS039是首个合成的,SIRT6的特异性激活剂,可在人癌细胞中诱导自噬,其EC50值为38μM.
Cas No.358721-70-7
Canonical SMILESN12C(C(C3=CC=CN=C3)NC4=C2C=CC=C4)=CC=C1
分子式C16H13N3
分子量247.29
溶解度DMSO : 125 mg/mL (505.48 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM[1]. SIRT6|38 μM (EC50)

UBCS039 (75 μM, 48 or 72 hours) induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells[2].UBCS039 leads to autophagosome accumulation in human cancer cells[2].UBCS039 induces autophagy via AMP-activated protein kinase (AMPK) signaling pathway activation[2]. Western Blot Analysis[2] Cell Line: Human H1299 cells.

[1]. Led to a strong decrease of cell proliferation in a dose-dependent manner when compared with control or DMSO-treated cells, starting from day 3 of growth (48 h after treatment) in both H1299 and HeLa cell lines. [2]. Sara Iachettini, et al. Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells. Cell Death and Disease (2018) 9:996.