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NSC 185058
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
NSC 185058图片
CAS NO:39122-38-8
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
NSC185058是一种ATG4B抑制剂。ATG4B是一种主要的半胱氨酸蛋白酶(cysteineprotease)。NSC185058显著减弱自噬(autophagic)活性。
Cas No.39122-38-8
Canonical SMILESS=C(C1=NC=CC=C1)NC2=NC=CC=C2
分子式C11H9N3S
分子量215.27
溶解度DMSO : ≥ 125 mg/mL (580.67 mM)
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. NSC185058 markedly attenuates autophagic activity[1]. ATG4B[1]Autophagy[1]

NSC185058 is an ATG4B antagonist. ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. Inclusion of the ATG4B inhibitor NSC185058 enhances the anti-tumor activity of radiation therapy (RT). NSC185058 decreases glioblastoma (GBM) cell tumorigenicity, and enhances the anti-tumor activity of RT when applied to orthotopic GBM xenograft models[1].

[1]. Huang T, et al. MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma. Cancer Cell. 2017 Dec 11;32(6):840-855.e8.