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GPP 78
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GPP 78图片
CAS NO:1202580-59-3
包装与价格:
包装价格(元)
500μg电议
1mg电议
5mg电议
10mg电议

产品介绍
GPP 78 (CAY10618) 是一种有效的 Nampt 抑制剂,对烟酰胺腺嘌呤二核苷酸 (NAD) 消耗的 IC50 为 3.0 nM。
Cas No.1202580-59-3
别名CAY10618
Canonical SMILESO=C(NC1=C(C2=CC=CC=C2)C=CC=C1)CCCCCCCN3N=NC(C4=CC=CN=C4)=C3
分子式C27H29N5O
分子量439.6
溶解度DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide into nicotinamide mononucleotide (NMN), which is subsequently converted to NAD+ by NMN adenyltransferase. Cancer cells commonly have an unusually high rate of NAD+ turnover, suggesting that inhibition of Nampt might selectively target cancer cells. GPP 78 is a potent inhibitor of Nampt (IC50 = 3 nM). It induces cell death in the neuroblastoma cell line SH-SY5Y with an IC50 value of 3.8 nM through a process that appears to involve autophagy.