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C18 dihydro Ceramide(d18:0/18:0)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
C18 dihydro Ceramide(d18:0/18:0)图片
CAS NO:2304-80-5
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍

A bioactive sphingolipid

Cas No.2304-80-5
别名二羟基神经酰胺,Cer(d18:0/18:0)
化学名N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-octadecanamide
Canonical SMILESO=C(CCCCCCCCCCCCCCCCC)N[C@@H](CO)[C@H](O)CCCCCCCCCCCCCCC
分子式C36H73NO3
分子量568
溶解度DMSO: Soluble,Ethanol: Warmed
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
文献引用
产品描述

C18 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C18 ceramide that lacks the 4,5-trans double bond. [1] Increased C18 dihydroceramide lipid levels lead to increased triacylglycerol storage and autophagosome accumulation as well as upregulation of the fibrosis markers α-SMA and FGF2 in Chang and LX-2 liver cells. C18 dihydro Ceramide is elevated in the plasma of pre-diabetics up to 9 years prior to the onset of type 2 diabetes. [2] It is also elevated in the skin of patients with lesional atopic dermatitis.[3]

Reference:
[1]. Lee, A.Y., Lee, J.W., Kim, J.-E., et al. Dihydroceramide is a key metabolite that regulates autophagy and promotes fibrosis in hepatic steatosis model. Biochem. Biophys. Res. Commun. 494(3-4), 460-469 (2017).
[2]. Wigger, L., Cruciani-Guglielmacci, C., Nicolas, A., et al. Plasma dihydroceramides are diabetes susceptibility biomarker candidates in mice and humans. Cell Rep. 18(9), 2269-2279 (2017).
[3]. Joo, J.-M., Hwang, J.-H., Bae, S., et al. Relationship of ceramide-, and free fatty acid-cholesterol ratios in the stratum corneum with skin barrier function of normal, atopic dermatitis lesional and non-lesional skins. J. Dermatol. Sci. 77(1), 71-74 (2015).