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Oxychlororaphine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Oxychlororaphine图片
CAS NO:550-89-0
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
100mg电议

产品介绍
 
Cas No.550-89-0
别名吩嗪-1-甲酰胺,phenazine-1-carboxamide
Canonical SMILESNC(C1=CC=CC2=C1N=C3C(C=CC=C3)=N2)=O
分子式C13H9N3O
分子量223.2
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Oxychlororaphine is a phenazine microbial metabolite that has been found in a variety of bacteria and has anticancer, antibacterial, and antifungal activities.1,2 It is cytotoxic to A549, HeLa, and SW480 cancer cells (IC50s = 32-40 μM).1 Oxychlororaphine halts the cell cycle at the G1 phase and induces apoptosis in A549 cells. It is active against Streptomyces bacteria and T. mentagrophytes, E. floccosum, C. albicans, M. audouini, and B. dermatitidis fungi when used at concentrations ranging from 12.5 to 50 ppm.2

References
1. Ali, H.M., El-Shikh, M.S., Salem, M.Z.M., et al. Isolation of bioactive phenazine-1-carboxamide from the soil bacterium Pantoea agglomerans and study of its anticancer potency on different cancer cell lines. J. AOAC Int. 99(5), 1233-1239 (2016).
2. Sierra, G., and Veringa, H.A. Effect of oxy-chlororaphin on the growth in vitro of Streptomyces species and some pathogenic fungi. Nature 182(4630), 265 (1958).