| CAS NO: | 910292-40-9 |
| 包装: | 1mg |
| 市场价: | 4460元 |
| Cas No. | 910292-40-9 |
| Canonical SMILES | O[C@]1(C)CC[C@@]2(COC(/C=C3[C@@H](O)[C@@]4(C(C)=O)OCC\3)=O)[C@@]5([H])[C@]1([H])C[C@@]6(O)[C@]2(C)[C@@](OC(/C=C/CC4)=O)([H])C[C@@]6([H])O5 |
| 分子式 | C29H38O10 |
| 分子量 | 546.6 |
| 溶解度 | DMSO: soluble,Ethanol: soluble,Methanol: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Myrothecine A is a trichothecene mycotoxin that has been found in M. roridum and has anticancer activities.1,2 It inhibits proliferation of A549, MCF-7, HepG2, and SMMC-7721 cancer cells (IC50s = 95, 70, 60, and 25 μM, respectively).1 Myrothecine A (50 μM) induces G1 cell cycle arrest in HepG2 cells, as well as increases Bax and cleaved caspase-3, -5, and -8 levels and induces apoptosis in SMMC-7721 cells.1,2 |1. Lin, T., Wang, G., Zhou, Y., et al. Structure elucidation and biological activity of two new trichothecenes from an endophyte, Myrothecium roridum. J. Agric. Food Chem. 62(25), 5993-6000 (2014).|2. Song, H., Fu, Y., Wan, D., et al. Mytoxin B and myrothecine A induce apoptosis in human hepatocarcinoma cell line SMMC-7721 via PI3K/Akt signaling pathway. Molecules 24(12), E2291 (2019). |
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