CHR 6494 trifluoroacetate

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	1458630-17-5
包装:	10mg
市场价:	2455元

产品介绍

CHR 6494 trifluoroacetate 是一种有效的 haspin 抑制剂，IC50 为 2 nM。 CHR 6494 trifluoroacetate 抑制组蛋白 H3T3 磷酸化。 CHR 6494 trifluoroacetate 诱导癌细胞凋亡，包括黑色素瘤和乳腺癌。 CHR 6494 trifluoroacetate 可用于癌症研究。

Cas No.	1458630-17-5
Canonical SMILES	CCCNC2=NN1C(C3=CC(C=NN4)=C4C=C3)=CN=C1C=C2.OC(C(F)(F)F)=O
分子式	C₁₆H₁₆N₆.CF₃CO₂H
分子量	406.36
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Potent and selective haspin kinase inhibitor (IC50 = 2 nM). Selective over 27 other protein kinases including Aurora B kinase. Induces cell cycle arrest at G2/M, inhibits cell proliferation and promotes apoptosis in multiple cancer cell lines. Inhibits angiogenesis ex vivo and attenuates tumor growth of HCT-116 xenografts in rats. Huertas et al (2012) Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene 31 1408 PMID:21804608