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Ribociclib D6 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ribociclib D6 hydrochloride图片
包装:5mg
市场价:5850元

产品介绍
Ribociclib D6 (LEE011 D6) hydrochloride 是 Ribociclib 的一种氘代化合物。Ribociclib 是一种高度特异性的 CDK4/6 抑制剂,IC50 值分别为 10 nM 和 39 nM,对 cyclin B/CDK1 复合体的活性低于其 1000 倍。
别名LEE011-d6 hydrochloride
分子式C23H25D6ClN8O
分子量477.04
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ribociclib D6 (LEE011 D6) hydrochloride is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1].

[1]. VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21(13):2905-10.