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Adenosine 3&rsquo-monophosphate(sodium salt hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Adenosine 3&rsquo-monophosphate(sodium salt hydrate)图片
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议

产品介绍
A nucleotide
Canonical SMILESOC[C@@H]1[C@@H](OP(O)(O)=O)[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O1.[Na].O
分子式C10H14N5O7P·XNa [XH2O]
分子量347.2
溶解度PBS (pH 7.2): 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Adenosine 3’-monophosphate is a nucleotide and metabolite formedviahydrolysis of 2’,3’-cAMP by metal-dependent phosphodiesterases.1It reduces proliferation of rat preglomerular vascular smooth muscles cells (PGVSMCs) and glomerular mesangial cells (GMCs) in a concentration-dependent manner, an effect that is abolished by the adenosine A2Breceptor antagonist MRS1754.2Adenosine 3’-monophosphate is also a metabolic intermediate in the biosynthesis of adenosine .

1.Rao, F., Yaning, Q., Murugan, E., et al.20,30-cAMP hydrolysis bymetal-dependent phosphodiesterases containing DHH, EAL, and HD domains is non-specific: Implications for PDE screeningBiochem. Bioph. Res. Commun.398(3)500-505(2010) 2.Jackson, E.K., Gillespie, D.G., and Dubey, R.K.2’-AMP and 3’-AMP inhibit proliferation of preglomerular vascular smooth muscle cells and glomerular mesangial cells via A2B receptorsJ. Pharmacol. Exp. Ther.337(2)444-450(2011)