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CTA 056
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CTA 056图片
CAS NO:1265822-30-7
包装:2mg
市场价:3763元

产品介绍
CTA 056 是一种 ITK(IL-2 诱导型 T 细胞激酶)抑制剂,IC50 为 0.1 μM。 CTA 056 选择性地靶向恶性 T 细胞并调节肿瘤细胞。 CTA 056 诱导细胞凋亡,是治疗 T 细胞白血病和淋巴瘤的潜在治疗剂。
Cas No.1265822-30-7
Canonical SMILESO=C2C(CC7=CC=CC=C7)=NC1=CC3=C(N=C(C5=CC=C(C6=CC=NC=C6)C=C5)N3CCCN4CCCCC4)C=C1N2
分子式C35H34N6O
分子量554.68
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Interleukin-2-inducible T-cell kinase (ITK) inhibitor (IC50 values are 0.1, 0.4 and 5 μM for ITK, BTK and ETK, respectively). Inhibits growth of cancer cells expressing ITK, including MOLT-4 and Jurkat cells in vitro. Induces apoptosis in Jurkat cells. Inhibits MOLT-4 xenograft tumor growth in mice.

Guo et al (2012) Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs. Mol.Pharmacol. 82 938 PMID:22899868