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6bK
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
6bK图片
CAS NO:1417537-93-9
包装:500 ug
市场价:4263元

产品介绍
6bK 是一种有效的选择性胰岛素降解酶 (IDE) 抑制剂,IC50 值为 50 nM。
Cas No.1417537-93-9
Canonical SMILESNC([C@@H](NC(/C=C/C(N[C@@H](CCCCN)C(N[C@H](C(N3)=O)CC2CCCCC2)=O)=O)=O)CCCCNC([C@H]3CC1=CC=C(C(C4=CC=CC=C4)=O)C=C1)=O)=O
分子式C41H55N7O7
分子量757.92
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Insulin degrading enzyme (IDE) inhibitor (IC50 = 50 nM); regulates insulin, glucagon and amylin levels, and improves glucose tolerance in a diabetic mouse model. This compound is supplied in net weight as the TFA salt.

Maianti et al (2014) Anti-diabetic activity of Ins-degrading enzyme inhibitors mediated by multiple hormones. Nature 511 94 PMID:24847884