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BMS 605541
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BMS 605541图片
CAS NO:639858-32-5
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Potent VEGFR-2 inhibitor
Cas No.639858-32-5
Canonical SMILESFC1=C(NCC2=CN=C(NC3=NC=CC=C3)S2)C=C(C(NC4CC4)=O)C(F)=C1
分子式C19H17F2N5OS
分子量401.43
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent ATP-competitive VEGFR-2 inhibitor (IC50 = 23 nM). Shows >10-fold selectivity for VEGFR-2 over VEGFR-1. Displays antitumor properties in human lung and colon tumor xenograft models. Orally bioavailable in rodents.

Borzilleri et al (2006) Discovery and evaluation of N-cyclopropyl- 2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5- ylmethyl)amino)benzamide (BMS-605541), a selective and orally efficacious inhibitor of vascular endothelial growth factor receptor-2. J.Med.Chem 49 3766 PMID:16789733