您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Squarunkin A hydrochloride
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Squarunkin A hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Squarunkin A hydrochloride图片
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Squarunkin A hydrochloride 是一种有效的、选择性的 UNC119-cargo 相互作用抑制剂(抑制 UNC119A-myristoylated Src N-末端肽相互作用的 IC50 为 10 nM)。 Squarunkin A hydrochloride 干扰细胞中 Src 激酶的激活。
Canonical SMILESCCOC(N1CCC(NC2=C(C(C2=O)=O)NCCN3CCN(C4=CC(C(F)(F)F)=CC=C4)CC3)CC1)=O.Cl
分子式C25H32F3N5O4.HCl
分子量560.01
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent inhibitor of UNC119 chaperone protein-cargo interaction (IC50 = 10 nM for inhibition of UNC119A - myristoylated Src N-terminal peptide interaction). Disrupts activation of Src kinase in vitro.

Mejuch et al (2017) Small-molecule inhibition of the UNC119-cargo interaction. Angew.Chem.Int.Ed. 56 6181 PMID:28471079