CAS NO: | 1303993-73-8 |
包装 | 价格(元) |
10mg | 电议 |
50mg | 电议 |
Cas No. | 1303993-73-8 |
化学名 | sodium (R)-2-amino-2-(2-chloro-5-hydroxyphenyl)acetate |
Canonical SMILES | ClC(C=C1)=C(C=C1O)[C@H](C([O-])=O)N.[Na+] |
分子式 | C8H7ClNNaO3 |
分子量 | 223.59 |
溶解度 | Soluble in DMSO |
储存条件 | Store at RT |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells[1]. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.[2]. CHPG sodium salt (10-500 μM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO2 derivatives treatment[1]. CHPG sodium salt (0.5 mM; 30 mins ) protects BV2 cells against SO2-induced apoptosis[1]. CHPG sodium salt (0.5 mM; 30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels[1]. CHPG sodium salt (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume[2]. References: |