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p38 MAPK Inhibitor IV
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
p38 MAPK Inhibitor IV图片
CAS NO:1638-41-1
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
p38 MAPK Inhibitor IV 是一种高度特异性的 ATP 竞争性 p38α； MAPK 抑制剂，IC50 为 0.13 和 0.55 μ；M 代表 p38α；和 p38β； MAPK，分别。
Cas No.1638-41-1
别名2,2'-磺酰基双(3,4,6-三氯苯酚),p38 MAP Kinase Inhibitor IV
化学名3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)sulfonyl]-phenol
Canonical SMILESClC1=CC(Cl)=C(C(S(C2=C(C(Cl)=CC(Cl)=C2O)Cl)(=O)=O)=C1O)Cl
分子式C12H4Cl6O4S
分子量456.9
溶解度2.5 mg/ml in DMSO, 2 mg/mL in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38 MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38x, and p38δ, respectively, in vitro.[1] It also inhibits LPS-induced TNF-α and IL-1β cytokine production (IC50s = 22 and 44 nM, respectively) in human peripheral blood mononuclear cells.

Reference:
[1]. Liu, Y.C., Ko, C.C., Cheng, F.C., et al. Identification of a novel competitive inhibitor of p38α MAPK by a human PBMC screen. Biochim. Biophys. Res. Commun. 352(3), 656-661 (2007).