您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Enterostatin(human,mouse,rat)(trifluoroacetate salt)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Enterostatin(human,mouse,rat)(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Enterostatin(human,mouse,rat)(trifluoroacetate salt)图片
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A pentapeptide involved in the regulation of food intake
Canonical SMILESN=C(N)NCCC[C@@H](C(O)=O)NC([C@H]1N(C(CNC([C@H]2N(C([C@H](C)N)=O)CCC2)=O)=O)CCC1)=O.OC(C(F)(F)F)=O
分子式C21H36N8O6·XCF3COOH
分子量496.6
溶解度DMF: 30 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Enterostatin is an endogenous pentapeptide fragment involved in the regulation of food intake.1It is released from its precursor protein, procolipase, during digestion and acts in the peripheral and central nervous systems to reduce food, especially fat, intake through the vagus nerve in the periphery and κ-opioid-, serotonin (5-HT) receptor subtype 5-HT1B-, and cholecystokinin-mediated signaling pathways in the brain.1,2Enterostatin binds to mitochondrial complex V, also known as F1F0ATP synthase, in a cell-free assay and inhibits ATP production and increases thermogenesis in INS-1 insulinoma cells.3It reduces body weight in rats fed a high-fat diet but not mice fed a chow diet. Enterostatin (1 nmol, i.c.v) reduces food intake in wild-type, but not melanocortin receptor 4 knockout (Mc4r-/-), mice.4It also enhances memory consolidation in mice in a passive avoidance test when administered at a dose of 300 mg/kg, an effect that can be blocked by the cholecystokinin 1 (CCK1) receptor antagonist lorglumide .5

1.York, D.A., and Park, M.Enterostatin, a peptide regulator of dietary fat ingestionHandbook of biologically active peptides969-974(2006) 2.Lin, L., and York, D.A.5-HT1B receptors modulate the feeding inhibitory effects of enterostatinBrain Res.1062(1-2)26-31(2005) 3.Berger, K., Sivars, U., Winzell, M.S., et al.Mitochondrial ATP synthase—a possible target protein in the regulation of energy metabolism in vitro and in vivoNurtr. Neurosci.5(3)201-210(2002) 4.Lin, L., Park, M., and York, D.A.Enterostatin inhibition of dietary fat intake is modulated through the melanocortin systemPeptides28(3)643-649(2007) 5.Ohinata, K., Sonoda, S., Shimano, T., et al.Enterostatin (APGPR) enhances memory consolidation in micePeptides28(3)719-721(2007)