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4-Acetamidobenzenesulfonamide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4-Acetamidobenzenesulfonamide图片
CAS NO:121-61-9
包装与价格:
包装价格(元)
50mg电议
100mg电议

产品介绍
A metabolite of asulam and sulfanilamide
Cas No.121-61-9
别名对乙酰胺基苯磺酰胺
Canonical SMILESO=C(C)NC1=CC=C(S(=O)(N)=O)C=C1
分子式C8H10N2O3S
分子量214.2
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:10): 0.09 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

4-Acetamidobenzenesulfonamide is a metabolite of the herbicide asulam and the sulfonamide antibiotic sulfanilamide .1,2,3It is formed from asulam by conversion to sulfanilamideviaintestinal microflora, followed by N4-acetylation in the liver. 4-Acetamidobenzenesulfonamide inhibits carbonic anhydrase II (CAII), CAIX, and CAXII (Kis = 246, 135, and 49 nM, respectively, for the human enzymes).4It has also been used in the synthesis of compounds with antibacterial activity.5

1.Heijbroek, W.M., Muggleton, D.F., and Parke, D.V.Metabolism of the carbamate herbicide, asulam, in the ratXenobiotica14(3)235-247(1984) 2.Okumura, F., Ueda, O., Kitamura, S., et al.N-acetylation and N-formylation of carcinogenic arylamines and related compounds in dogsCarcinogenesis16(1)71-76(1995) 3.Olsen, H., and MØrland, J.Sulfonamide acetylation in isolated rat liver cellsActa Pharmacol. Toxicol. (Copenh)49(2)102-109(1981) 4.Ozensoy, O., Puccetti, L., Fasolis, G., et al.Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamidesBioorg. Med. Chem. Lett.15(21)4862-4866(2005) 5.Wang, X.-L., Wan, K., and Zhou, C.-H.Synthesis of novel sulfanilamide-derived 1,2,3-triazoles and their evaluation for antibacterial and antifungal activitiesEur. J. Med. Chem.45(10)4631-4639(2010)