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N-Butyldeoxynojirimycin-d9(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N-Butyldeoxynojirimycin-d9(hydrochloride)图片
CAS NO:1883545-57-0
包装与价格:
包装价格(元)
500 µg电议
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of N-butyldeoxynojirimycin
Cas No.1883545-57-0
别名[2H9]-N-丁基脱氧野尻霉素盐酸盐,N-Butyldeoxynojirimycin-d9 hydrochloride; NB-DNJ-d9 hydrochloride; OGT 918-d9 hydrochloride
Canonical SMILES[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])N1C[C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O.Cl
分子式C10H12D9NO4·HCl
分子量264.8
溶解度DMF: soluble,DMSO: soluble,Methanol: soluble,Water: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N-Butyldeoxynojirimycin-d9(NB-DNJ-d9) is intended for use as an internal standard for the quantification of NB-DNJ by GC- or LC-MS. NB-DNJ is an iminosugar that inhibits UDP-glucose ceramide glucosyltransferase and β-glucosidase 2 (IC50s = 32 and 81 μM, respectively, for the rat recombinant enzymes).1It also increases the activity of wild-type acid β-glucosidase, as well as the S364R, N370S, V15M, or M123T mutants, in COS-7 cells expressing the human enzymes when used at a concentration of 10 µM.2NB-DNJ also inhibits HIV-1 and HIV-2 infection of peripheral blood mononuclear cells (PBMCs; IC50s = 282 and 211 μM, respectively).3Formulations containing NB-DNJ have been used in the treatment of Gaucher disease, an inborn error of metabolism characterized as a lysosomal storage disorder resulting from substantial deficiency of β-glucosidase.

1.Lee, J.C., Francis, S., Dutta, D., et al.Synthesis and evaluation of eight- and four-membered iminosugar analogues as inhibitors of testicular ceramide-specific glucosyltransferase, testicular β-glucosidase 2, and other glycosidasesJ. Org. Chem.77(7)3082-3098(2012) 2.Alfonso, P., PampÍn, S., Estrada, J., et al.Miglustat (NB-DNJ) works as a chaperone for mutated acid β-glucosidase in cells transfected with several Gaucher disease mutationsBlood Cells Mol. Dis.35(2)268-276(2005) 3.Pollock, S., Dwek, R.A., Burton, D.R., et al.N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome deliveryAIDS22(15)1961-1969(2008)