| CAS NO: | 6336-34-1 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 6336-34-1 |
| 别名 | NSC39047 |
| Canonical SMILES | NC(C1=CC=C(OC2=CC=C(C(N)=O)C=C2)C=C1)=O |
| 分子式 | C14H12N2O3 |
| 分子量 | 256.3 |
| 溶解度 | DMF: 5 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | OUL35 is an inhibitor of poly(ADP-ribose) polymerase 10 (PARP10; IC50 = 329 nM).1 It is selective for PARP10 over a panel of 15 PARP enzymes, including PARP4, PARP14, and PARP16 (IC50s = 22.6, 23.4, and 4.17 μM, respectively). OUL35 (10 μM) reverses inhibition of HeLa cell proliferation induced by PARP10 overexpression. It sensitizes HeLa cells to hydroxyurea , increasing hydroxyurea-induced inhibition of cell proliferation when used at a concentration of 5 μM. |1. Venkannagari, H., Verheugd, P., Koivunen, J., et al. Small-molecule chemical probe rescues cells from mono-ADP-ribosyltransferase ARTD10/PARP10-induced apoptosis and sensitizes cancer cells to DNA damage. Cell Chem. Bio. 23(10), 1251-1260 (2016). |
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