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(R)-BAY-598
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(R)-BAY-598图片
CAS NO:1906920-28-2
包装与价格：
包装价格(元)
500μg电议
1mg电议
5mg电议
10mg电议

产品介绍
An inhibitor of SMYD2
Cas No.1906920-28-2
Canonical SMILESClC1=C(Cl)C=CC(C2=NN(/C(NC3=CC=CC(OC(F)F)=C3)=N\C#N)C[C@H]2N(C(CO)=O)CC)=C1
分子式C22H20Cl2F2N6O3
分子量525.3
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(R)-BAY-598 is an inhibitor of the lysine N-methyltransferase SMYD2 (IC50 = 1.7 μM) and a less active enantiomer of (S)-BAY-598 .1 It is selective for SMYD2 over proteinase-activated receptor 1 (PAR1; IC50 = >30 μM).

|1. Eggert, E., Hillig, R.C., Koehr, S., et al. Discovery and characterization of a highly potent and selective aminopyrazoline-based in vivo probe (BAY-598) for the protein lysine methyltransferase SMYD2. J. Med. Chem. 59(10), 4578-4600 (2016).