| CAS NO: | 2416095-00-4 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 2416095-00-4 |
| Canonical SMILES | OC(CN[C@@H](C1)[C@@H](S(C2=CC=C(Cl)C(Cl)=C2)(=O)=O)CS1(=O)=O)=O |
| 分子式 | C12H13Cl2NO6S2 |
| 分子量 | 402.27 |
| 溶解度 | DMSO: 200 mg/mL (497.18 mM) |
| 储存条件 | 4℃, stored under nitrogen |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CBR-470-2, a glycine-substituted analog, can activate NRF2 signaling. CBR-470-2 can be used for the research of modulation glycolysis[1]. CBR-470-2 (1-10 μM; 24 h) increases transcript levels of the NRF2-responsive genes NQO1 and HMOX1 in epidermal keratinocytes and dermal fibroblasts[1]. CBR-470-2 (50 mg/kg; p.o. twice daily for 10 d) induces activation of NRF2 signaling in vivo[1]. Animal Model: Balb/C mice (5-week old) are exposed to UVB[1] [1]. Bollong MJ, et, al. A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. Nature. 2018 Oct;562(7728):600-604. |
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