| CAS NO: | 614-47-1 |
| 包装: | 500mg |
| 市场价: | 450元 |
| Cas No. | 614-47-1 |
| 别名 | 反-查耳酮 |
| Canonical SMILES | O=C(C1=CC=CC=C1)/C=C/C2=CC=CC=C2 |
| 分子式 | C15H12O |
| 分子量 | 208.26 |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity[1][2][3]. trans-Chalcone competitively inhibits porcine pancreatic α-amylase with a Ki of 48 µM[2]. trans-Chalcone (30.23-98.03 µM; 24 hours) induces cell cycle arrest and apoptosis in MCF-7 cells[1]. trans-Chalcone (20-80 µM; 24, 48 hours) reduces the expression of the apoptosis-related protein Bcl-2[1]. trans-Chalcone (58.25 µM; 6, 24 hours) has greater inhibition of Bcl-2, induction of APAF1 and BAX, and strong induction of CIDEA in 24 hours[1]. trans-Chalcone (24 hours) inhibits MCF-7 cell viability (IC20=30.23 µM; IC50=58.25 µM; IC80=98.03 µM). trans-Chalcone (48 h) has IC50s of 41.53 µM and 48.41 µM for MCF-7 and 3T3 cell lines, respectively. trans-Chalcone exhibits a pronounced cytotoxicity activity[1]. References: |
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