| CAS NO: | 1568-80-5 |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 1568-80-5 |
| 别名 | 3,3,3',3'-四甲基-1,1'-螺BI(茚满)-6,6'-二醇 |
| 分子式 | C21H24O2 |
| 分子量 | 308.41 |
| 溶解度 | DMSO : 125 mg/mL (405.30 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8[1]. HIV-1 integrase inhibitor 8 is against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn2+ as the cationic cofactor by gel assay with IC50 values of 275 µM and 200 µM, respectively. It inhibits the strand-transfer (ST) activity with an IC50 value of 200 µM[1].The DNA relaxation activity of MCV topoisomerase is monitored by gel electrophoresis, while DNA cleavage and religation activities were monitored using a microtiter assay. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC50 values of 500 µM and 200 µM, respectively. This result demonstrates that compound 8 is inactive against topoisomerase in both assays[1]. HIV-1 integrase inhibitor 8 induces cell cytotoxicity and yields a LD50 (dose at which the signal is reduced 50% due to cell death) of 20 μM in HeLa cells[1]. [1]. Molteni, et al. A New Class of HIV-1 Integrase Inhibitors: The 3,3,3’, 3’-tetramethyl-1,1’-spirobi(indan)-5,5’,6,6’-tetrol Family.J Med Chem |
m.cnreagent.com