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AP39
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AP39图片
CAS NO:1429173-57-8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
AP39 是一种三苯基鏻衍生的茴香脑二硫代硫酮和线粒体靶向硫化氢 (H2S) 供体。
Cas No.1429173-57-8
Canonical SMILESS=C(SS1)C=C1C(C=C2)=CC=C2OC(CCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O
分子式C37H38O2PS3
分子量641.9
溶解度DMF: 5 mg/ml,DMSO: 20 mg/ml,Ethanol: 16 mg/ml,PBS (pH 7.2): 1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP39 (30-300 nM) dose-dependently increases H2S levels in endothelial cells, predominantly in mitochondrial regions. It stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an inhibitory effect at 300 nM. Under oxidative stress conditions induced by glucose oxidase, AP39 has antioxidant and cytoprotective effects. AP39 is effective in vivo, inhibiting voltage-dependent T-type calcium channels and improving hemodynamic parameters in rats.