| CAS NO: | 1884269-07-1 |
| 包装 | 价格(元) |
| 500 μg | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 1884269-07-1 |
| 别名 | AHU-377-d4 |
| Canonical SMILES | C[C@@H](C(OCC)=O)C[C@H](NC(C([2H])([2H])C([2H])([2H])C(O)=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1 |
| 分子式 | C24H25D4NO5 |
| 分子量 | 415.5 |
| 溶解度 | Chloroform: Slightly Soluble,DMSO: Slightly Soluble,Methanol: Slightly Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | AHU377-d4is intended for use as an internal standard for the quantification of AHU377 by GC- or LC-MS. AHU377 is a methyl ester prodrug form of the neprilysin inhibitor LBQ657 .1It increases plasma levels of atrial natriuretic factor (ANF) in conscious rats and anesthetized dogs when administered at doses of 10 and 30 mg/kg, respectively. AHU377 (30 mg/kg) increases ANF-induced urinary sodium excretion in anesthetized rats. Formulations containing AHU377 in combination with valsartan have been used in the treatment of mild to moderate hypertension and chronic heart failure. 1.Ksander, G.M., Ghai, R.D., deJesus, R., et al.Dicarboxylic acid dipeptide neutral endopeptidase inhibitorsJ. Med. Chem.38(10)1689-1700(1995) |
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