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BI-847325
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BI-847325图片
CAS NO:1207293-36-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品名称
BI 847325, BI847325
产品介绍

生物活性

BI-847325是一种生物利用型选择性MEK/Aurora双重激酶抑制剂,对于非洲爪蟾Aurora B,人Aurora A和Aurora C以及IC50分别为3 nM,25 nM,15 nM,25 nM和4 nM IC50人MEK1和MEK2。

靶点信息

Aurora B (Xenopus laevis)MEK2Aurora C (Human)Aurora A (Human)MEK1
3 nM4 nM15 nM25 nM25 nM

化学数据

目录号A15762
作用机制Inhibitor (抑制剂)
M. Wt464.56
FormulaC29H28N4O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1207293-36-4
SynonymsBI 847325, BI847325
SMILESCCNC(C#CC1=CC=C2C(NC(/C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC=CC=C4)=O)=C1)=O

溶解度

In vitro (25°C)DMSOWarmed: 19 mg/mL (40.89 mM)
WaterInsoluble
Ethanol1 mg/mL (2.15 mM)
In vivo2-hydroxyethyl cellulose, polysorbate 80 with pH adjusted to 2.8 with 1 M HCl28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM21.53 mL107.63 mL215.26 mL
0.5 mM4.31 mL21.53 mL43.05 mL
1 mM2.15 mL10.76 mL21.53 mL
5 mM0.43 mL2.15 mL4.31 mL

*The above data is based on the productmolecular weight 464.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.