您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > 9-cis-β-Carotene
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
9-cis-β-Carotene
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
9-cis-β-Carotene图片
CAS NO:13312-52-2
包装:1mg
市场价:22950元

产品介绍
9-cis-β-Carotene 一种视网膜的前体 (precursor),由 β-胡萝卜素加氧酶 1 (BCMO1) 裂解产生 9-cis-retinal。9-cis-β-Carotene 在动物模型中抑制视网膜光感受器变性和帮助恢复视网膜功能。9-cis-β-Carotene 有潜力用于先天性静止夜盲症的研究。
Cas No.13312-52-2
别名(9Z)-Β-胡萝卜素
分子式C40H56
分子量536.87
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal. 9-cis-β-Carotene inhibits photoreceptor degeneration and restores retinal function in vivo. 9-cis-β-Carotene has the potential for the study of congenital stationary night blindness and fundus albipunctatus[1].

9-cis-β-Carotene (1 μM; 18 hours) formulates with the Miglyol 810 and the"antioxidant mix" is incubated to eye cups. The eye cups are isolated from the neuro-retina attached to the underlying RPE tissue from RPE65rd12 mouse. It prevents S- and M-cones degeneration and leads to over 2- and 9- fold higher m-opsin and s-opsin positive staining compares to the control group[1].

In a mouse model of retinoid cycle defect, RPE65rd12. Mice with an extract of Dunaliella Bardawil algae rich in 9-cis-β-Carotene (9CBC) rescues retinal function and preserves cone structure by oral administration[1].

[1]. Sher I, et al.Synthetic 9-cis-beta-carotene inhibits photoreceptor degeneration in cultures of eye cups from rpe65rd12 mouse model of retinoid cycle defect.Sci Rep. 2018 Apr 17;8(1):6130.