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4-Hydroxymephenytoin D3
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
4-Hydroxymephenytoin D3图片
CAS NO:1173022-56-4
包装:5mg
市场价:7920元

产品介绍
4-Hydroxymephenytoin D3 是 4-Hydroxymephenytoin 的氘代物。4-Hydroxymephenytoin 是抗癫痫药 mephenytoin 的代谢物; mephenytoin 为 CYP2C19 的一种配体。
Cas No.1173022-56-4
别名4羟基美芬妥英
分子式C12H11D3N2O3
分子量237.27
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

4-Hydroxymephenytoin D3 is the deuterium labeled 4-Hydroxymephenytoin. 4-Hydroxymephenytoin is a metabolism of an antiepileptic drug mephenytoin, which is used as a CYP2C19 substrate[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2]. Tanaka M, et al. Simple and selective assay of 4-hydroxymephenytoin in human urine using solid-phase extraction and high-performance liquid chromatography with electrochemical detection and its preliminary application to phenotyping test. J Chromatogr B Biomed Appl. 1996 Feb 9;676(1):87-94.
[3]. Stewart NA, et al. A UPLC-MS/MS assay of the "Pittsburgh cocktail": six CYP probe-drug/metabolites from human plasma and urine using stable isotope dilution. Analyst. 2011 Feb 7;136(3):605-12.