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2-Nonylquinolin-4(1H)-one
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
2-Nonylquinolin-4(1H)-one图片
CAS NO:55396-45-7
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
A quinolone alkaloid with diverse biological activities
Cas No.55396-45-7
别名2-壬基喹啉-4(1H)-酮
Canonical SMILESO=C1C=C(CCCCCCCCC)NC2=C1C=CC=C2
分子式C18H25NO
分子量271.4
溶解度DMF: 30 mg/ml,DMSO: 15 mg/ml,Ethanol: 30 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

2-Nonylquinolin-4(1H)-one is a quinolone alkaloid that has been found inP. aeruginosaand has diverse biological activities.1,2,3,4It reduces infection of Huh7.5 cells by hepatitis C virus (HCV) with an IC50value of 1.4 µg/ml.12-Nonylquinolin-4(1H)-one (50 and 100 µg/ml) is also active againstL. gongylophorus, a symbiotic fungus of the agricultural pestA. sexdens(leaf-cutting ant).2It inhibits activation of nuclear factor of activated T cells (NFAT) induced by phorbol 12-myristate 13-acetate and the calcium ionophore A23187 in Jurkat cells (IC50= 3.44 µM), but not LPS-induced NF-κB activation in RAW 264.7 cells (IC50= >100 µM), in reporter assays.3This compound is expected to exist in one or both tautomeric forms, depending on experimental conditions.

1.Wahyuni, T.S., Widyawaruyanti, A., Lusida, M.I., et al.Inhibition of hepatitis C virus replication by chalepin and pseudane IX isolated from Ruta angustifolia leavesFitoterapia99276-283(2014) 2.Biavatti, M.W., Vieira, P.C., da Silva, F.d.G.F., et al.Biological activity of quinoline alkaloids from Raulinoa echinata and x-ray structure of flindersiamineJ. Braz. Chem. Soc.13(1)66-70(2002) 3.Jin, H.Z., Lee, J.H., Lee, D., et al.Quinolone alkaloids with inhibitory activity against nuclear factor of activated T cells from the fruits of Evodia rutaecarpaBiol. Pharm. Bull.27(6)926-928(2004) 4.Ortori, C.A., Dubern, J.-F., Chhabra, S.R., et al.Simultaneous quantitative profiling of N-acyl-L-homoserine lactone and 2-alkyl-4(1H)-quinolone families of quorum-sensing signaling molecules using LC-MS/MSAnal. Bioanal. Chem.399(2)839-850(2011)