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1-Alaninechlamydocin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
1-Alaninechlamydocin图片
CAS NO:141446-96-0
包装与价格:
包装价格(元)
500μg电议
2.5mg电议

产品介绍
1-Alaninechlamydocin 是一种环状四肽,是一种有效的 HDAC 抑制剂 (IC50=6.4 nM)。 1-Alaninechlamydocin 在 MIA PaCa-2 细胞中诱导 G2/M 细胞周期停滞和凋亡。
Cas No.141446-96-0
Canonical SMILESO=C(N[C@@H](CCCCCC([C@@H]1CO1)=O)C(N[C@H]2C)=O)[C@]3([H])N(CCC3)C([C@H](CC4=CC=CC=C4)NC2=O)=O
分子式C27H36N4O6
分子量512.6
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

1-Alaninechalmydocin is a fungal metabolite originally isolated from a Great Lakes-derived Tolypocladium sp. and an inhibitor of histone deacetylases (HDACs). It reduces total HDAC activity in HeLa cell lysates in a concentration-dependent manner. 1-Alaninechlamydocin reduces proliferation of MIA PaCa-2, PANC-1, and hTERT-HPNE cells (GI50s = 5.3, 14, and 2.0 nM, respectively).