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(-)-Rasfonin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(-)-Rasfonin图片
CAS NO:303156-68-5
包装与价格：
包装价格(元)
500μg电议
1mg电议
5mg电议

产品介绍
(-)-Rasfonin 是一种真菌次生代谢物，可抑制小 G 蛋白 Ras。 (-)-Rasfonin 在 ACHN 细胞（一种肾癌细胞系）中诱导细胞凋亡、坏死和自噬。
Cas No.303156-68-5
别名拉斯弗宁
化学名(2E,4E,6S)-8-hydroxy-6-(hydroxymethyl)-4-methyl-2,4-octadienoic acid, (2R,3R)-3,6-dihydro-6-oxo-2-[(1S,3R,5E)-1,3,5-trimethyl-5-hepten-1-yl]-2H-pyran-3-yl ester
Canonical SMILESO=C1O[C@@]([C@@H](C)C[C@@H](C)C/C(C)=C/C)([H])[C@H](OC(/C=C/C(C)=C/[C@@H](CO)CCO)=O)C=C1
分子式C25H38O6
分子量434.6
溶解度DMSO: 1 mg/ml,Ethanol: Soluble,Methanol: Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(-)-Rasfonin is a fungal metabolite that has been found in T. terrophilus.1 It inhibits proliferation of mouse splenocytes induced by concanavalin A and LPS (IC50s = 0.7 and 0.5 μg/ml, respectively).

References
1. Fujimoto, H., Okamoto, Y., Sone, E., et al. Eleven new 2-pyrones from a fungi imperfecti, Trichurus terrophilus, found in a screening study guided by immunomodulatory activity. Chem. Pharm. Bull. (Tokyo) 53(8), 923-929 (2005).