| Cas No. | 23537-16-8 |
| 别名 | 细皱青霉素+FORM,(+)-Rugulosin |
| 化学名 | (5aS,6R,13aS,14R,17S,18R,19R,20S)-1,7,9,15,17,20-hexahydroxy-3,11-dimethyl-5H,6H-6,13a,5a,14-[1,2,3,4]butanetetraylcycloocta[1,2-b:5,6-b']dinaphthalene-5,8,13,16(14H)-tetrone |
| Canonical SMILES | CC1=CC(O)=C(C(C2=C(O)[C@]3([H])[C@]4(C(C5=CC(C)=CC(O)=C5C6=O)=O)C6=C(O)[C@@]([H])([C@](O)([H])[C@]4([H])[C@@]7([H])[C@]3([H])O)[C@]27C8=O)=O)C8=C1 |
| 分子式 | C30H22O10 |
| 分子量 | 542.5 |
| 溶解度 | DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (+)-Rugulosin is a pigment and mycotoxin produced by certain fungi. It inhibits HIV-1 integrase activity with IC50 values of 19 and 25 uM in coupled and strand transfer assays, respectively. It also inhibits ribonuclease H in rat liver by 83% at a concentration of 157 uM and ribonucleases H1, H2, and H3 in T. pyriformis by 100, 99, and 100%, respectively, at a concentration of 313 uM. (+)-Rugulosin leads to hepatic injury and liver cell hyperplasia in mice when administered in the diet. It is cytotoxic to insect cells but not mammalian C6/36, L929, and HepG2 cells (ID50s = 1.2, >200, 23.7, and >200 ug/ml, respectively). |
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